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Bioreactor Design and Performance Research
Bioreactor is a very important biochemical process equipment, widely used in biotechnology, pharmaceutical industry, food industry, environmental protection and other fields. The design and performance research of bioreactor is very important, which can determine its production efficiency and product quality. This article aims to introduce the knowledge related to the design and performance research of bioreactor.
Bailun 50L-100L-SJA stainless steel fermenter
Bioreactor Design
The design of a bioreactor is a complex process that requires consideration of many factors, such as the material, shape, size, inlet and outlet locations, stirring method, perfusion method, ventilation method, etc. of the reaction vessel. The selection of these factors directly affects the biological reaction process and its effect in the reactor.
(1)Selection of reaction vessels
The selection of reaction vessels is very important. Generally speaking, the materials should have good chemical stability, high temperature tolerance, pressure tolerance and physical and mechanical properties. For example, glass reactors are suitable for handling low temperature, low pressure and small reactors; stainless steel reactors are suitable for handling medium temperature, high pressure and large reactors.
(2)Shape of reaction vessel
The shape of the reaction vessel will also affect the fluid mechanics characteristics in the reactor, thereby affecting the speed and efficiency of the reaction. Generally speaking, cylindrical and spherical reaction vessels have less impact on fluid flow and are more suitable for suspension culture; while flat and elongated reaction vessels perform better in mass transfer and mixing and are suitable for liquid culture.
(3)Size of reaction vessel
The volume of the reactor directly affects the production capacity of the reactor. When selecting the size of the reactor, it is necessary to consider factors such as production needs, biological species and properties, and the inhibitory effects of reactants and products to determine a reasonable reactor volume.
(4)Selection of inlet and outlet positions
The inlet and outlet positions of reactants and products determine the operation mode and automation degree of the reactor. Therefore, the inlet and outlet positions should consider the convenience and practicality of the production operation process and the automation control of on-site equipment.
(5)Stirring method
The stirring method also has a great impact on the biological reaction in the reactor. Different types of organisms require different stirring methods. For example, some strains require strong stirring, while others are sufficient for light stirring. The choice of stirring method should be based on the maximum speed, stirring power and related physical parameters required by the bioreactor.
(6）Perfusion and ventilation methods
Perfusion and ventilation methods are also important design parameters. The selection of these parameters can meet the needs of reactants and products, improve mixing, improve mixing quality, and prevent vortexes and unevenness in the reactor.
Bailun 5L mechanical stirring glass bioreactor BLBIO-GJ
Performance study of bioreactor
The study of bioreactor performance is an important part of bioreactor design, and its purpose is to optimize the operating efficiency and reaction output of the reactor and improve production effects and economic benefits.
(1)Monitoring of reactor environment
The environment in the reactor has a key influence on the effect of biological reaction. Therefore, it is necessary to monitor the environmental changes in the reactor, including parameters such as temperature, pH value, oxygen content, stirring speed, liquid level, etc., to achieve dynamic adjustment and optimization of reaction process parameters.
(2)Selection and optimization of biological species
Biological species selection is one of the key links in the study of bioreactor performance. Different biological species have different reaction characteristics and growth conditions. For specific application purposes and reactor design requirements, it is necessary to maximize the reaction yield and rate by screening and optimizing biological species, so as to maximize production benefits.
(3)Fluid mechanics research of reactors
The fluid mechanics research of reactors has an important influence on the mixing effect of biological reactions in reactors, gas-liquid mass transfer efficiency, vortex in reactors, etc. Therefore, in reactor design, it is necessary to conduct a comprehensive study and analysis of the fluid mechanics properties of different reactor types, adjust the fluid field and material transfer conditions in the reactor, so as to improve the reaction performance such as mixing effect and mass transfer efficiency in the reactor.
(4)Biochemical reaction kinetics research
The study of biological reaction kinetics in reactors refers to the study of the dynamic process of material transformation, proliferation and death in the reaction process. By establishing the reaction kinetics model of each biological component, its metabolic capacity and formation rate are determined to optimize the reactor operating parameters, thereby achieving the effect of production optimization.
Bioreactor is a very important biochemical technology equipment, widely used in many fields. The design and performance research of bioreactor is the key factor to improve the production efficiency and product quality of the reactor. During the design phase, factors such as the material, shape, size, inlet and outlet position, stirring method, perfusion method and ventilation method of the reaction vessel should be considered. In the performance research, attention should be paid to the monitoring of the reactor environment, the selection and optimization of biological species, the fluid mechanics research of the reactor and the biochemical reaction kinetics research. In the design and performance research of the bioreactor, various factors should be considered comprehensively, and the reactor design parameters should be continuously optimized so that it can meet the ever-increasing production needs.
About Bailun
Bailun has extensive experience in manufacturing various types of bioreactors and pressure vessels. It has a team of experts in the fields of bioreactors, fermentation processes, mechanical manufacturing, and automated control. Its scientific research and technological level are always at the leading domestic and world-class level, providing you with a comfortable, assured, and secure product experience.